Thibaut Douché

This study targets the Sec61 translocon to suppress pathogenic light-chain production in AL amyloidosis, showing that mycolactone and synthetic inhibitors like A317 reduce LC secretion while highlighting the need for client selectivity.

This paper introduces a normalization framework to decouple protocol and instrument effects in multicenter proteomics studies, demonstrating its application to the PME13 dataset.

The paper uses a five-layer systems analysis to show that protein degradation, not genomic changes, drives stage differentiation in Leishmania parasites.

The paper introduces diagFDR, a framework to improve FDR reporting in proteomics by assessing scope, calibration, and stability, and provides tools for verification.

The paper describes a method to simultaneously extract high-quality RNA and proteins from the same mosquito samples, enabling both RNA-Seq and LC-MS proteomic analyses.

This study shows fumarate-based drugs modify gut bacteria via cysteine succination, affecting their functions and interactions in both isolated cultures and microbial communities.

This study identifies plasma protein biomarkers for early detection of gastric preneoplasia and cancer using proteomics and validation in a cohort, showing high classification performance.

This study identifies ATG16L1's role in IAV-induced PI4P production at the ER, facilitating vRNP egress by coordinating RAB11A and PI4P-enriched membranes.

This study tracks genetic and phenotypic changes in Yersinia enterocolitica during a chronic human infection, revealing host-adaptive mutations and antibiotic resistance mechanisms.

This study characterizes DNA-carrying extracellular vesicles (EVs) from Methanobrevibacter smithii, revealing their role in DNA and protein export in the gut.

This study harmonizes quality controls across proteomics core facilities to improve data comparability and reliability through a 4-year longitudinal dataset and common processing software.

The paper presents a dual proteomic analysis of Yersinia pestis and human immune cells during blood infection, revealing pathogenic signatures and pathway reshaping.