Author
Sophia UniversityORCID 0000-0002-9996-8913Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Luca Nishimura, Hiroaki Unno, Kyoko Kurihara, Mai Suganami, Junna Kawasaki, Spyros Lytras, Kaho Okumura, Edward Charles Holmes, Jumpei Ito, Kei Sato
The paper develops a host-response-based framework to detect viral infections by analyzing ISG expression in RNA-seq data from diverse species, revealing hidden infections missed by conventional methods.
bioRxiv · Mar 16, 2026 · PreprintMicrobiology
Jumpei Ito, Shusuke Kawakubo, Hiroaki Unno, Adam Patrick Strange, Spyros Lytras, Kaho Okumura, Alice Lilley, Ruth Harvey, Nicola S. Lewis, Kei Sato
This study uses a protein language model to map influenza virus antigenicity from genotype data, revealing evolutionary patterns and improving vaccine strain selection.
bioRxiv · Aug 4, 2025 · PreprintMicrobiology
Jumpei Ito, Adam Patrick Strange, Wei Liu, Gustav Joas, Spyros Lytras, Keita Matsuno, Naganori Nao, Hirofumi Sawa, Keita Mizuma, Isshu Kojima, Jingshu Li, Tomoya Tsubo, Shinya Tanaka, Masumi Tsuda, Lei Wang, , Kei Sato
This paper introduces CoVFit, a protein language model that predicts SARS-CoV-2 variant fitness using spike protein sequences, identifying fitness-enhancing mutations and predicting emerging variants.
Nature Communications · May 13, 2025Peer-reviewedMicrobiology
Shuhei Tsujino, Masumi Tsuda, Naganori Nao, Kaho Okumura, Lei Wang, Yoshitaka Oda, Yume Mimura, Jingshu Li, Rina Hashimoto, Yasufumi Matsumura, Rigel Suzuki, Saori Suzuki, Kumiko Yoshimatsu, Miki Nagao, Jumpei Ito, , Takasuke Fukuhara
This study investigates the evolutionary changes from BA.2.86 to JN.1, showing that non-spike protein mutations compensate for reduced spike protein replication, enhancing viral fitness.
bioRxiv · Feb 17, 2025 · PreprintMicrobiology
Yu Kaku, Kaho Okumura, Shusuke Kawakubo, Keiya Uriu, Chen Luo, Yusuke Kosugi, Yoshifumi Uwamino, MST Monira Begum, Sharee Leong, Terumasa Ikeda, Kenji Sadamasu, Hiroyuki Asakura, Mami Nagashima, Kazuhisa Yoshimura, Jumpei Ito, Kei Sato
This study analyzes the virological characteristics of the SARS-CoV-2 XEC variant, showing it has higher infectivity and immune evasion compared to KP.3.1.1, contributing to its higher reproductive number and potential dominance.
The Lancet Infectious Diseases · Nov 6, 2024Peer-reviewedMicrobiology
Yu Kaku, Keiya Uriu, Kaho Okumura, Jumpei Ito, Kei Sato
This paper investigates the virological properties of the SARS-CoV-2 KP.3.1.1 variant, finding it has higher transmissibility and immune evasion compared to KP.3.
The Lancet Infectious Diseases · Aug 16, 2024Peer-reviewedMicrobiology
Yu Kaku, Maximilian Stanley Yo, Jarel Elgin Tolentino, Keiya Uriu, Kaho Okumura, Jumpei Ito, Kei Sato
This study evaluates the virological properties of SARS-CoV-2 variants KP.3, LB.1, and KP.2.3, finding higher reproduction numbers and immune evasion compared to JN.1.
The Lancet Infectious Diseases · Jun 27, 2024Peer-reviewedMicrobiology
Yu Kaku, Keiya Uriu, Yusuke Kosugi, Kaho Okumura, Daichi Yamasoba, Yoshifumi Uwamino, Jin Kuramochi, Kenji Sadamasu, Kazuhisa Yoshimura, Hiroyuki Asakura, Mami Nagashima, Jumpei Ito, Kei Sato
This study investigates the virological properties of the SARS-CoV-2 KP.2 variant, finding it has higher viral fitness and immune resistance compared to JN.1, contributing to its rapid spread.
The Lancet Infectious Diseases · May 20, 2024Peer-reviewedMicrobiology