Keita Matsuno

Integrated in vivo and transcriptomic analyses of lethal Oropouche virus infection reveal suppression of pathogenic host responses by antiviral therapy

This study shows favipiravir suppresses OROV replication and disease in hamsters, preventing neuroinvasion and pathogenic host responses through transcriptomic analysis.

Reverse genetics system for emerging tick-borne orthonairovirus highlights dispensable N-terminal region of Gn associated with replication in tick vectors

This study develops a reverse genetics system for Yezo virus to investigate the role of its glycoprotein N-terminal region in replication across mammalian and tick hosts.

Spatial distribution of ticks and tick-borne pathogens in central Hokkaido, Japan and associated ecological factors revealed by intensive short-term survey in 2024

This study maps the spatial distribution of ticks and tick-borne pathogens in central Hokkaido, Japan, and identifies ecological factors influencing their distribution.

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

This study identifies the non-spike R204P mutation in the SARS-CoV-2 Omicron XEC variant as a driver of increased inflammation and pathogenicity through NF-κB activation.

A Protein Language Model for Exploring Viral Fitness Landscapes

This paper introduces CoVFit, a protein language model that predicts SARS-CoV-2 variant fitness using spike protein sequences, identifying fitness-enhancing mutations and predicting emerging variants.

First versatile reverse genetics system for feline coronavirus

This paper establishes a reverse genetics system for feline coronavirus to generate recombinant viruses for studying pathogenesis and antiviral responses.

Evolution of BA.2.86 to JN.1 reveals functional changes in non-structural viral proteins are required for fitness of SARS-CoV-2

This study investigates the evolutionary changes from BA.2.86 to JN.1, showing that non-spike protein mutations compensate for reduced spike protein replication, enhancing viral fitness.

N-glycolylneuraminic acid binding of avian H7 influenza A viruses

The paper investigates how avian H7 influenza A viruses can bind NeuGc through specific mutations, revealing insights into viral adaptation to NeuGc receptors.