Author

Marc P. M. Soutar

UCL Queen Square Institute of NeurologyORCID 0000-0003-0008-9423Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Hélène Plun‐FavreauiD· 4 shared Benjamin J. O’CallaghaniD· 3 shared Daniela MelandriiD· 2 shared Sonia GandhiiD· 2 shared Alan Michael PittmaniD· 1 shared Alastair D. ReithiD· 1 shared Alexander J. WhitworthiD· 1 shared Alice RockliffeiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Hélène Plun‐FavreauORCID

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4 papers

Recent·Most cited

NeuroscienceAutophagy ReportsPeer-reviewedJun 12, 2026

Glucose concentration of neuronal media formulations influences PINK1-dependent mitophagy in human iNeurons

Benjamin J. O’Callaghan, Daniela Melandri, Darija Šoltić…·Hélène Plun‐Favreau

This study shows that glucose levels in neuronal culture media affect PINK1-dependent mitophagy in human iNeurons, with BrainPhys medium reducing mitophagy compared to N2B27.

1 citation

humanbulk RNA-seq

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NeurosciencebioRxivPreprintJun 10, 2025

A CRISPR-CAS9 high throughput machine-learning platform for modulation of genes involved in Parkinson's disease-associated PINK1-mitophagy in iPSC-derived dopaminergic neurons

Marc P. M. Soutar, Benedetta Carbone, Petya Kindalova…·Hélène Plun‐Favreau

The paper develops a CRISPR-CAS9 platform with machine learning to study PINK1-mitophagy in Parkinson's disease using iPSC-derived neurons, identifying key genes and validating their roles.

DOI 10.1101/2025.06.10.658840

humanCRISPR screen

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NeuroscienceScientific ReportsPeer-reviewedMay 22, 2024

KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy

Capucine de Talhouët, Noemí Esteras, Marc P. M. Soutar…·Hélène Plun‐Favreau

This study shows that KAT8 inhibition via MG149 blocks PINK1-dependent mitophagy initiation but promotes mitochondrial delivery to lysosomes without toxins.

10 citations

experimental assay

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NeuroscienceBrainPeer-reviewedSep 7, 2022

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at Chr16q11.2 and on the MAPT H1 allele

Marc P. M. Soutar, Daniela Melandri, Benjamin J. O’Callaghan…·Hélène Plun‐Favreau

The paper identifies KAT8 and KANSL1 as regulators of PINK1-mitophagy linked to Parkinson's disease risk, suggesting a novel pathway for therapeutic targeting.

60 citationstop 2%

humanwhole-genome sequencing

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