NeuroscienceiSciencePeer-reviewed
Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
Yan Guo, Alison A. Chomiak, Ye Hong…·Yuanyi Feng
This study shows Brap loss leads to H2A ubiquitination, causing aging hallmarks and neurodegeneration in mice, with similar findings in Alzheimer's human brain tissue.