Author

Emily Maguire

UK Dementia Research InstituteORCID 0000-0003-0046-318XUnclaimed ORCID profile · follow to get notified of new preprints

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Emily Maguire1 paper

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Julie H. WilliamsiD· 3 shared Philip R. TayloriD· 3 shared Nicholas D. AlleniD· 2 shared Rebecca SimsiD· 2 shared Tom J. PhillipsiD· 2 shared Atahualpa Castillo-MoralesiD· 1 shared Bethany GearyiD· 1 shared Bethany ShawiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

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10 top collaborators · 40 mutual co-author links

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3 shared papersNeuroscience

Julie H. WilliamsORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintMay 1, 2026

New Human IPSC Models of Late-onset Alzheimer's Disease Polygenic Risk Identify Multiple Impairments of Microglial Function

Hazel Hall‐Roberts, Emily Maguire, Bethany Shaw…·Julie H. Williams

This study uses human iPSC-derived microglia with high polygenic AD risk to identify functional impairments in immune response, mitochondrial function, and amyloid-beta uptake.

DOI 10.64898/2026.04.29.721607

humanbulk RNA-seq

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NeurosciencebioRxivPreprintSep 22, 2023

Uncoupling of synaptic loss from amyloid burden by an Alzheimer's disease protective variant of PLCγ2.

Ryan J. Bevan, Emily Maguire, Tom J. Phillips…·Philip R. Taylor

This study identifies a protective PLCG2 variant that preserves synaptic integrity and reduces microglial synapse engulfment in Alzheimer's disease, independent of amyloid burden.

1 citation

humanexperimental assay

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NeurosciencebioRxivPreprintApr 27, 2020

The Alzheimer's disease protective P522R variant of PLCG2, consistently enhances stimulus-dependent PLCγ2 activation, depleting substrate and altering cell function.

Emily Maguire, Georgina Elizabeth Menzies, Tom J. Phillips…·Philip R. Taylor

This paper identifies a protective PLCG2 variant in Alzheimer's disease, showing enhanced PLCγ2 activation and functional changes in immune cells.

4 citations

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