Georgina Elizabeth Menzies

Structure, function and dynamics of mCoral, a pH responsive engineered variant of the mCherry fluorescent protein with improved hydrogen peroxide tolerance.

The paper describes the engineering of mCoral, a modified mCherry variant with improved hydrogen peroxide tolerance and pH responsiveness, and elucidates its structural and dynamic properties.

FAN1 nuclease activity affects CAG expansion and age at onset of Huntington's disease

The paper identifies FAN1 nuclease activity as a modifier of CAG expansion and age at onset in Huntington's disease through exome sequencing and functional validation.

The Alzheimer's disease protective P522R variant of PLCG2, consistently enhances stimulus-dependent PLCγ2 activation, depleting substrate and altering cell function.

This paper identifies a protective PLCG2 variant in Alzheimer's disease, showing enhanced PLCγ2 activation and functional changes in immune cells.

Genetic association study of psychotic experiences in UK Biobank

This study conducts the largest genetic association analysis of psychotic experiences in the UK Biobank, identifying four genome-wide significant loci and showing shared genetic risk with schizophrenia, depression, bipolar disorder, and neurodevelopmental disorders.

Molecular Dynamics simulations of Alzheimer's variants, R47H and R62H, in TREM2 provide evidence for structural alterations behind functional changes

The paper uses molecular dynamics simulations to show that Alzheimer's-associated TREM2 variants R47H and R62H cause structural changes, with R47H having a larger impact on the protein's binding loop.