Philip R. Taylor

The paper uses polygenic risk scores to analyze genetic contributions to neurodegenerative diseases across brain cell types, finding shared and disease-specific genetic risks.

The paper identifies GATA6's role in regulating sphingolipid and CysLT metabolism in peritoneal macrophages, leading to eosinophil survival via CysLT signaling.

This paper develops a highly efficient lentiviral transduction method for human iPSC-derived microglia and macrophages using a modified promoter and plasmid design.

This study uses human iPSC-derived microglia with high polygenic AD risk to identify functional impairments in immune response, mitochondrial function, and amyloid-beta uptake.

This study identifies a protective PLCG2 variant that preserves synaptic integrity and reduces microglial synapse engulfment in Alzheimer's disease, independent of amyloid burden.

This study shows that altering Spi1 levels in mouse microglia affects transcriptomic pathways, suggesting a link between Spi1 and AD-related immune responses.

This study shows Abi3 is essential for microglial morphology, distribution, and tissue surveillance in vivo, linking it to Alzheimer's disease risk.

This paper identifies a protective PLCG2 variant in Alzheimer's disease, showing enhanced PLCγ2 activation and functional changes in immune cells.