Author

Megan Oliva

University of CambridgeORCID 0000-0003-0101-8985Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:Drosophila· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

Cahir J. O’KaneiD· 2 shared Juan José Pérez-MorenoiD· 2 shared Cristiana Mattei· 1 shared Erlina S. Mohamed Syazwan· 1 shared Filomena GalloiD· 1 shared Ingrid Eileen SchefferiD· 1 shared Jillian O’Shaughnessy· 1 shared Karin H. MülleriD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersNeuroscience

Cahir J. O’KaneORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Emerging neurodevelopmental mechanisms in patient induced pluripotent stem cells-derived spheroids modelling SCN1A Dravet Syndrome

Cristiana Mattei, Miaomiao Mao, Sean Byars, Erlina S. Mohamed Syazwan, Megan Oliva, Timothy J Karle, Kay Richards, Ingrid Eileen Scheffer, Steven Petrou, Snezana Maljevic

This study uses patient-derived iPSC spheroids to model SCN1A Dravet Syndrome, revealing dysregulated developmental processes and predicting drug response to fenfluramine.

bioRxiv · May 9, 2024 · PreprintNeuroscience

Drosophila SPG12 ortholog, reticulon-like 1, governs presynapticER organization and Ca2+ dynamics

Juan José Pérez-Moreno, Rebecca C. Smith, Megan Oliva, Filomena Gallo, Shainy Ojha, Karin H. Müller, Cahir J. O’Kane

This study shows that loss of Rtnl1 in Drosophila disrupts presynaptic ER organization and causes defects in Ca2+ dynamics and neurotransmission.

The Journal of Cell Biology · Feb 25, 2023Peer-reviewedNeuroscience

Endoplasmic reticulum (ER) lumenal indicators in Drosophila reveal effects of HSP-related mutations on ER calcium dynamics

Megan Oliva, Juan José Pérez-Moreno, Jillian O’Shaughnessy, Trevor J. Wardill, Cahir J. O’Kane

The paper develops ER lumenal Ca2+ sensors in Drosophila to study how HSP-related mutations affect ER calcium dynamics in motor neurons.

Frontiers in Neuroscience · Aug 10, 2020Peer-reviewedNeuroscience