Molecular BiologybioRxivPreprint
Somatic DIS3 mutations in Multiple Myeloma arise early in clonal evolution, but are later counterselected due to toxicity
Tomasz M. Kuliński, Olga Gewartowska, Seweryn Mroczek…·Andrzej Dziembowski
This study shows that DIS3 mutations in multiple myeloma arise early but are later counterselected due to toxicity, with loss-of-heterozygosity reversing their effects.
3 citations