Andrzej Dziembowski

This study shows TENT5A polyadenylates enamel matrix protein mRNAs, enhancing their stability and translation, which is essential for proper enamel mineralization.

The paper develops segmented polyA tail designs to improve DNA stability and mRNA translatability, finding that longer segmented tails significantly enhance protein production.

This study uses nanopore sequencing to analyze polyadenylation changes in rat hippocampi during long-term potentiation, revealing dynamic shifts in poly(A) tail length and composition.

This paper introduces a chemical method to circularize in vitro transcribed RNA, producing chemically circularized RNAs (chem-circRNAs) with high efficiency and compatibility with modifications.

This study shows DIS3L is essential for mouse embryo development but not cell viability, as its absence causes severe embryo degeneration and impaired protein synthesis without affecting cell survival or transcriptome levels.

The paper investigates the role of nematode-specific NSPC genes in C. elegans, finding that their deletion affects insulin signaling rather than defense response.

The paper shows that TENT5C and LARP4/5 work together to maintain globin mRNA poly(A) tails during erythropoiesis, ensuring proper hemoglobin production.

This study shows that TENT2-dependent microRNA tailing affects synaptic transmission and excitatory/inhibitory balance in the hippocampus of mice.

This study identifies TENT-5 as a regulator of male-specific gene expression in C. elegans through polyadenylation, though its absence does not affect mating behavior or fertility.

This study shows DIS3 mutations in multiple myeloma increase AID-dependent IgH translocations by altering chromatin interactions and RNA processing.

This study shows that DIS3 mutations in multiple myeloma arise early but are later counterselected due to toxicity, with loss-of-heterozygosity reversing their effects.

A mutation in the TRAP1 gene causes autism-like behaviors in male mice, suggesting a role for mitochondrial protein homeostasis in male-specific autism.

The paper shows that mRNA deadenylation and decay are globally correlated, but deadenylation is not indispensable for decapping, and decapping can initiate on short pA-tails bound by Pab1.

This paper identifies URT1 as a TUTase that connects decapping activators and prevents excessive deadenylation of mRNAs, thereby avoiding siRNA biogenesis in Arabidopsis.

The paper uses high-throughput siRNA screening to identify functional interactions and redundancies among human processive exoribonucleases in RNA metabolism.

The paper shows that mitochondrial proteins are locally synthesized at synapses and incorporated into respiratory chain complexes, supporting local mitochondrial biogenesis.

This study identifies TENT5A as a cytoplasmic poly(A) polymerase essential for collagen production and bone formation, revealing its role in osteogenesis imperfecta type XVIII.

The paper develops a versatile vector system for protein functional analysis and stable cell line generation using FLP-mediated recombination, validated with multiple protein tags and applications.