Tomasz M. Kuliński

This study shows DIS3L is essential for mouse embryo development but not cell viability, as its absence causes severe embryo degeneration and impaired protein synthesis without affecting cell survival or transcriptome levels.

This study shows DIS3 mutations in multiple myeloma increase AID-dependent IgH translocations by altering chromatin interactions and RNA processing.

This study shows that DIS3 mutations in multiple myeloma arise early but are later counterselected due to toxicity, with loss-of-heterozygosity reversing their effects.

The paper shows that mitochondrial proteins are locally synthesized at synapses and incorporated into respiratory chain complexes, supporting local mitochondrial biogenesis.

The paper develops a versatile vector system for protein functional analysis and stable cell line generation using FLP-mediated recombination, validated with multiple protein tags and applications.