Seweryn Mroczek

This study shows TENT5A polyadenylates enamel matrix protein mRNAs, enhancing their stability and translation, which is essential for proper enamel mineralization.

The paper develops segmented polyA tail designs to improve DNA stability and mRNA translatability, finding that longer segmented tails significantly enhance protein production.

This study uses nanopore sequencing to analyze polyadenylation changes in rat hippocampi during long-term potentiation, revealing dynamic shifts in poly(A) tail length and composition.

This study shows DIS3L is essential for mouse embryo development but not cell viability, as its absence causes severe embryo degeneration and impaired protein synthesis without affecting cell survival or transcriptome levels.

This study shows that DIS3 mutations in multiple myeloma arise early but are later counterselected due to toxicity, with loss-of-heterozygosity reversing their effects.

The paper shows that mRNA deadenylation and decay are globally correlated, but deadenylation is not indispensable for decapping, and decapping can initiate on short pA-tails bound by Pab1.

This paper identifies URT1 as a TUTase that connects decapping activators and prevents excessive deadenylation of mRNAs, thereby avoiding siRNA biogenesis in Arabidopsis.

This study identifies TENT5A as a cytoplasmic poly(A) polymerase essential for collagen production and bone formation, revealing its role in osteogenesis imperfecta type XVIII.