Rebekah G. Langston

This study uses snRNA-seq to analyze age-related transcriptional changes in four brain regions across young and aged individuals, identifying region-specific age-associated genes and biological processes.

The paper uses single-cell RNA sequencing to assess the impact of Lrrk2 mutations on neuroinflammation in mice, finding limited transcriptional effects.

This paper develops 3D brain organoids with endothelial and neural cells using sequential differentiation of iPSC-derived embryoid bodies, showing enhanced angiogenesis and SARS-CoV-2 receptor expression.

The paper shows that a non-coding genetic variant affects LRRK2 expression specifically through microglia, highlighting the importance of cell type in understanding non-coding variation's role in Parkinson's disease.

This study shows LAG3 is not expressed in human and mouse neurons and does not worsen α-synuclein pathology in vitro or in vivo.

This paper identifies genetic pathways and cell types involved in ALS using polygenic risk scores and Mendelian randomization, finding convergence on specific biological processes and cell types.

The paper identifies genetic modifiers of risk and age at onset in GBA-associated Parkinson disease and Lewy body dementia using large case-control datasets and genome-wide association studies.