Liam Horan-Portelance

Semi-automated annotation refinement accelerates cell type identification in brain spatial and single-cell studies

SAHA provides a statistical framework for rapid cell type annotation by transferring labels from reference datasets to query datasets without integration.

Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTD

The paper identifies molecular subtypes of neurons in the frontoinsular cortex and links specific gene expression patterns to neuronal vulnerability in FTD.

Single cell RNA sequencing reveals limited effects of Lrrk2 genotype in a mouse model of acute CNS inflammation

The paper uses single-cell RNA sequencing to assess the impact of Lrrk2 mutations on neuroinflammation in mice, finding limited transcriptional effects.

Integrative analysis reveals generalizable human neurodegenerative disease-associated glial states

This study identifies generalizable glial states across multiple neurodegenerative diseases using integrative single-cell transcriptomic analysis of multi-region atlases.

Imaging spatial transcriptomics reveals molecular patterns of vulnerability to pathology in a transgenic α-synucleinopathy model

The paper uses imaging spatial transcriptomics to identify neuronal subtypes vulnerable to -synuclein pathology in a transgenic mouse model and finds Plk2 and hSNCA expression are key to pathology development.