Author

Jean‐Philippe Loeffler

InsermORCID 0000-0003-0166-5496Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Shyuan Thieu NgoiD· 2 shared Alberto FerriiD· 1 shared Alexandre HenriquesiD· 1 shared Bradley J. TurneriD· 1 shared Cristiana ValleiD· 1 shared Dean KelkiD· 1 shared Elyse Wimberger· 1 shared Fleur C. GartoniD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Shyuan Thieu NgoORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 30, 2022

Profound lipid dysregulation in mutant TDP-43 mice is ameliorated by the glucocerebrosidase 2 inhibitor ambroxol

Sophia J. Luikinga, Alexandre Henriques, Shyuan Thieu Ngo…·Bradley J. Turner

This study identifies lipid dysregulation in TDP-43 mutant mice and shows ambroxol improves motor function and preserves neurons by modulating glycosphingolipid metabolism.

4 citations

mousestatistical model

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NeuroscienceBrain CommunicationsPeer-reviewedJan 1, 2020

Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis (ALS)

Frederik J. Steyn, Rui Li, Siobhan E. Kirk…·Shyuan Thieu Ngo

This study investigates altered glucose-fatty acid flux in ALS using mouse models and patient-derived myotubes, finding increased fatty acid oxidation linked to slower disease progression but with metabolic heterogeneity across patients.

67 citationstop 4%

mousehuman

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