Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis (ALS)
Frederik J. Steyn, Rui Li, Siobhan E. Kirk, Tesfaye Wolde Tefera, T. Y. Xie, Timothy J. Tracey, Dean Kelk, Elyse Wimberger, Fleur C. Garton, Llion Arwyn Roberts, Sarah E. Chapman, Jeff Scott Coombes, W. Matthew Leevy, Alberto Ferri, Cristiana Valle, , Shyuan Thieu Ngo
This study investigates altered glucose-fatty acid flux in ALS using mouse models and patient-derived myotubes, finding increased fatty acid oxidation linked to slower disease progression but with metabolic heterogeneity across patients.
Brain Communications · Jan 1, 2020Peer-reviewedNeuroscience