Sarah A. Woodson

The paper develops an analytical theory to predict dwell-time distributions in biomolecular condensates based on single-molecule measurements of RNA dwell times.

This study identifies snR37 as a bifunctional H/ACA snoRNP that both pseudouridylates rRNA and scaffolds ribosome assembly during pre-60S intermediate formation.

The paper investigates the folding behavior of expanded HTT mRNA and finds that stick-slip dynamics contribute to its aggregation propensity.

This study uses time-resolved DMS footprinting to show that rRNA tertiary interactions and protein binding sites in E. coli remain unfolded until late stages of ribosome assembly.

This study shows that expanded ATXN2 transcripts are toxic and disrupt rRNA processing in SCA2, similar to expanded HTT transcripts in HD, suggesting a shared mechanism in repeat expansion diseases.

This study investigates Era's role in 30S ribosomal subunit assembly using mass spectrometry, cryo-EM, and in-cell footprinting, showing that most rRNA domains can fold without Era and that Era binding affects the decoding center.