Anthony K. Henras

This study identifies Drs1 as a key RNA helicase that facilitates the incorporation of 25S rRNA domain III during early pre-60S ribosome maturation by interacting with Erb1 and remodeling pre-rRNA.

This study identifies snR37 as a bifunctional H/ACA snoRNP that both pseudouridylates rRNA and scaffolds ribosome assembly during pre-60S intermediate formation.

The paper shows that premature termination of transcription by RNA polymerase I limits rRNA production and that a mutant polymerase, SuperPol, reduces this termination, increasing rRNA output.

The paper identifies Sni445 as a novel factor that recruits snR4 and snR45 snoRNPs to 90S pre-ribosomes, enabling Kre33-mediated acetylation of 18S rRNA.

This study identifies a macromolecular assembly involving snR190 and the Npa1 complex that is essential for 60S ribosomal subunit maturation in yeast.

This study identifies a family of lncRNAs, including FRG2A, whose overexpression in FSHD patients disrupts nucleolar architecture and reduces protein synthesis, linking FSHD to muscle wasting.

The paper identifies Neat1 and paraspeckle components as translational regulators that facilitate IRES-dependent translation during hypoxia in mouse cardiomyocytes.

The paper shows RSK phosphorylates RIOK2, promoting pre-40S particle maturation and ribosome synthesis in human cells.

The paper identifies mutations in RNA polymerase I that enhance its activity, leading to increased rRNA production in yeast.

The paper shows that ribosome assembly stress triggers a pathway that balances Hsf1 and Ifh1 activity to prevent proteotoxic stress in yeast.