Lucie Laplane

The paper shows clonal memory in human HSPCs persists across divisions and is disrupted in AML, with potential for therapeutic modulation.

The paper identifies CXCL8 secreted by immature granulocytes as a factor inhibiting wildtype hematopoiesis in CMML, suggesting CXCL8 blockade could slow disease progression.

This study shows that combining DNA hypomethylating agents with H3K9me2 inhibitors reactivates immune pathways and eliminates malignant stem cells in CMML by targeting heterochromatin disorganization.

The paper generates a high-quality reference transcriptome for Platynereis dumerilii and analyzes RNA-seq data from posterior regeneration stages to identify gene expression dynamics and key molecular mechanisms.