Françoise Porteu

This study shows that transient reprogramming with Yamanaka factors delays and partially reverses HSC aging and stress-induced decline by limiting AP-1 chromatin opening and transposable element activation.

The paper shows that Tet2-deficient HSCs are resistant to LPS-induced L1 derepression and genomic instability, which contributes to their clonal expansion under chronic inflammation.

The paper identifies CXCL8 secreted by immature granulocytes as a factor inhibiting wildtype hematopoiesis in CMML, suggesting CXCL8 blockade could slow disease progression.

This study shows that combining DNA hypomethylating agents with H3K9me2 inhibitors reactivates immune pathways and eliminates malignant stem cells in CMML by targeting heterochromatin disorganization.