Author

Jakub Cibulka

Masaryk UniversityORCID 0000-0003-0304-3180Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Lumír KrejčíiD· 2 shared Alexandra Sisáková· 1 shared Anik MitraiD· 1 shared Benoît CarbainiD· 1 shared Changfeng DengiD· 1 shared Chetan C. RawaliD· 1 shared Chiara MeriglianoiD· 1 shared Christopher P. CaridiiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Lumír KrejčíORCID

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2 papers

Recent·Most cited

Molecular BiologyJournal of Medicinal ChemistryPeer-reviewedFeb 25, 2026

Discovery of two structurally distinct classes of inhibitors targeting the nuclease MUS81 and enhancing efficacy of chemotherapy in cancer cells

Jana Prochazkova, Benoît Carbain, Victoria Marini…·Lumír Krejčí

This paper identifies two distinct MUS81 inhibitors that enhance chemotherapy efficacy by impairing DNA repair in cancer cells.

1 citation

experimental assaydrug response / drug discovery

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Cell BiologyMolecular CellPeer-reviewedDec 8, 2023

'Off-pore' nucleoporins relocalize heterochromatic breaks through phase separation

Chiara Merigliano, Taehyun Ryu, Jakub Cibulka…·Irene Chiolo

The paper shows that Nup98 nucleoporins use phase separation to mobilize heterochromatic repair sites and exclude Rad51, promoting homologous recombination and genome integrity.

17 citations

humanDNA methylation

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