Author

Maarten van Dinther

Leiden University Medical CenterORCID 0000-0002-9451-8884Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Ananya MukundaniD· 2 shared Andrew P. HinckiD· 2 shared Cynthia S. HinckiD· 2 shared Peter ten DijkeiD· 2 shared Rick M. MaizelsiD· 2 shared Caroline S. HilliD· 1 shared Claire Ciancia· 1 shared Gerard van der ZoniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

Ananya MukundanORCID

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Author profile →

2 papers

Recent·Most cited

Decoding the Mechanism of Action of a Parasite TGFβAntagonist Inspires the Creation of Cell-type-specific TGFβ Modulators

Maarten van Dinther, Tristin A. Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Román González‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke

This paper identifies co-receptors for a parasite TGFβ antagonist, uses structural data to design cell-type-specific TGFβ modulators, and demonstrates their selective antagonistic effects.

Advanced Science · Apr 20, 2026Peer-reviewedBiochemistry

Pro-domain-dependent folding and co-receptor-mediated targeting to optimize an antagonistic TGF-β monomer for gene-based delivery

Łukasz Wieteska, Cynthia S. Hinck, Ananya Mukundan, Troy C. Krzysiak, Maarten van Dinther, Thibault Vantieghem, Rick M. Maizels, Peter ten Dijke, Caroline S. Hill, Andrew P. Hinck

This paper improves the folding and targeting of an engineered TGF-β monomer for gene-based delivery by modifying its pro-domain and adding a CD44 binding domain.

bioRxiv · Mar 24, 2026 · PreprintBioengineering