Author

Signe Simonsen

University of CopenhagenORCID 0000-0003-0376-7488Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Birthe Brandt KragelundiD· 2 shared Andreas PresteliD· 1 shared Emily HelgeseniD· 1 shared Eva Christina Østerlund· 1 shared Ida Mathilde Marstein Riisnæs· 1 shared James Alexander BoothiD· 1 shared Kirsten SkarstadiD· 1 shared Krister VikedaliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

Birthe Brandt KragelundORCID

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2 papers

Recent·Most cited

MicrobiologyNucleic Acids ResearchPeer-reviewedMay 27, 2026

The RecBCD complex interacts directly with the DNA sliding clamp in Escherichia coli

Ida Mathilde Marstein Riisnæs, Synnøve Brandt Ræder, Signe Simonsen…·Emily Helgesen

This paper identifies a direct interaction between the RecBCD complex and the DNA sliding clamp in E. coli, showing its role in DNA repair and survival after DNA damage.

1 citation

E. coliexperimental assay

𝕏 PostBluesky

BiophysicsProteins Structure Function and BioinformaticsPeer-reviewedJul 26, 2025

Responses to ligand binding in the bacterial DNA sliding clamp beta-clamp manifest in dynamic allosteric effects

Signe Simonsen, Andreas Prestel, Eva Christina Østerlund…·Birthe Brandt Kragelund

This study investigates how ligand binding affects the dynamics of the bacterial DNA sliding clamp beta-clamp using NMR and hydrogen-deuterium exchange mass spectrometry, revealing dynamic allosteric effects.

3 citations

bacteria (other)protein structure

𝕏 PostBluesky