Author

Julius L. Decano

Brigham and Women's HospitalORCID 0000-0003-0388-3585Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:rat· 1

Frequent Co-Authors

Arda HaluiD· 2 shared Joseph LoscalzoiD· 2 shared Masanori AikawaiD· 2 shared Albert-Ĺaszló BarabásiiD· 1 shared Amitabh SharmaiD· 1 shared Edwin K. SilvermaniD· 1 shared Joan T. MatamalasiD· 1 shared João FadistaiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersSystems Biology

Arda HaluORCID

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2 papers

Recent·Most cited

Systems BiologyGenome MedicinePeer-reviewedJan 20, 2025

Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery

Arda Halu, Sarvesh Chelvanambi, Julius L. Decano…·Masanori Aikawa

This paper introduces Pathopticon, a network-based method integrating pharmacogenomics, cheminformatics, and disease phenotypes to prioritize cell lines and drugs for cell type-guided drug discovery.

7 citations

statistical modeldrug response / drug discovery

𝕏 PostBluesky

Systems Biologynpj Systems Biology and ApplicationsPeer-reviewedJun 11, 2018

Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes

Amitabh Sharma, Arda Halu, Julius L. Decano…·Joseph Loscalzo

The paper identifies NFATC4 as a key regulator of Type 2 Diabetes genes by analyzing a gene regulatory network in pancreatic islets and linking it to eQTLs and differential expression.

30 citationstop 4%

ratbulk RNA-seq

𝕏 PostBluesky