Masanori Aikawa

Platelet-endothelial crosstalk drives distinct endothelial dysfunction in bicuspid aortic valve disease

This study shows that platelet-derived signals cause distinct endothelial dysfunction in bicuspid aortic valve disease, leading to mitochondrial dysfunction and immune cell recruitment.

Multiparametric Extracellular Vesicle Profiling Identifies a Distinct Circulating Signature of Bicuspid Aortic Valve Disease

This study identifies a distinct circulating extracellular vesicle signature in bicuspid aortic valve disease through single-vesicle analysis and proteomic profiling.

Proteomic and Kinetic Analyses Reveal Discordant Apolipoprotein Turnover and Support a Revised Model of Human Lipoprotein(a) Metabolism

The paper uses proteomic and kinetic analyses to show that APO(a) and APOB in Lp(a) particles have different turnover rates, suggesting a revised model of Lp(a) metabolism.

Multi-Omics Mapping of Human Kidney Reveals Complement-Mediated Cellular Dynamics During Progression of Focal Segmental Glomerulosclerosis

This study uses multi-omics approaches to analyze human kidney biopsies and identifies complement-mediated cellular dynamics in FSGS progression, highlighting key signaling changes in podocytes and parietal epithelial cells.

Selective PPAR-α activation with pemafibrate attenuates macrophage-mediated progression of calcific aortic valve disease

This study shows pemafibrate reduces calcific aortic valve disease by modulating macrophage-VIC interactions, independent of lipid lowering.

PARP14 is an interferon (IFN)-induced host factor that promotes IFN production and affects the replication of multiple viruses

This paper shows PARP14 promotes IFN production and has both antiviral and proviral functions against multiple viruses.

Sexual Dimorphism of Plasma and Tissue Proteomes in Human Calcific Aortic Valve Stenosis Pathogenesis

This study identifies sex-specific proteomic differences in calcific aortic valve stenosis, revealing distinct molecular mechanisms in males and females.

Nanoparticle-enabled plasma proteomics of a mouse atherosclerosis model

This study uses nanoparticle-enhanced plasma proteomics to identify low-abundant proteins in atherosclerosis-prone mice, revealing disease-related changes in inflammation, lipid metabolism, and potential biomarkers.

Cross-species proteomics quantification pipeline distinguishes donor versus host extracellular matrix in explanted biomaterials

The paper develops a cross-species proteomics pipeline to distinguish donor and host ECM proteins in explanted biomaterials, showing that single-species analysis leads to inaccurate quantification.

Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery

This paper introduces Pathopticon, a network-based method integrating pharmacogenomics, cheminformatics, and disease phenotypes to prioritize cell lines and drugs for cell type-guided drug discovery.

Novel Role of Endothelial CD45 in Regulating Endothelial-to-Mesenchymal Transition in Atherosclerosis

This study shows that deleting CD45 in endothelial cells reduces atherosclerosis by inhibiting EndoMT and TGFβ signaling through increased FGFR2 and KLF2 expression.

Short-term Pre-operative Methionine Restriction Induces Browning of Perivascular Adipose Tissue and Improves Vein Graft Remodeling in Mice

Conserved and Divergent Modulation of Calcification in Atherosclerosis and Aortic Valve Disease by Tissue Extracellular Vesicles

The paper isolates and analyzes extracellular vesicles from atherosclerotic plaques and aortic valves, identifying shared and distinct molecular pathways involved in calcification.

Endothelial-derived sphingolipids are required for vascular development and systemic lipid homeostasis

This study shows that endothelial-derived sphingolipids are essential for vascular development and systemic lipid homeostasis, with effects on retinal vascularization and liver toxicity.

Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

The paper characterizes S1PR1-regulated transcriptomes in aortic endothelial cells, revealing distinct subtypes and signaling mechanisms in arterial and lymphatic endothelium.

Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

The paper characterizes the transcriptomic and epigenomic landscape of nine human endothelial cell types, identifying EC-specific enhancers and marker genes, and highlights the role of HOX genes in vascular development and disease.

Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes

The paper identifies NFATC4 as a key regulator of Type 2 Diabetes genes by analyzing a gene regulatory network in pancreatic islets and linking it to eQTLs and differential expression.