Edoardo Fatti

This study uses Scanning Ion Conductance Microscopy to measure the material properties of biomolecular condensates, showing how pH and protein tags affect their stiffness over time.

The paper uses solution scattering and simulations to show that Dhh1's modular architecture allows structural heterogeneity while maintaining functional specificity.

This study shows that fluorescent and poly-histidine tags alter the condensation properties of Dhh1 in vitro and P-body numbers in vivo, raising concerns about the reliability of tagged protein condensation experiments.