Neuronal NOX4 knockdown alleviates pathological tau-related alterations in a humanized mouse model of tauopathy
Enrique Luengo, Paula Trigo-Alonso, Cristina Fernández‐Mendívil, Ángel Núñez, Marta del Campo, César Porrero, Nuria García‐Magro, Pilar Negredo, Cristina Sánchez‐Ramos, Juan Antonio Bernal, Alberto Rábano, Jeroen J.M. Hoozemans, Ana Isabel Casas, Harald H.H.W. Schmidt, Ana María Cuervo, Manuela G. López
This study shows that reducing NOX4 in neurons alleviates tau-related pathology and cognitive decline in a mouse model of tauopathy.
bioRxiv · Oct 14, 2020 · PreprintNeuroscience