Author

Fleur S. van de Bovenkamp

Leiden University Medical CenterORCID 0000-0003-0507-268XUnclaimed ORCID profile · follow to get notified of new preprints

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Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Douwe J. DijkstraiD· 1 shared Leendert Adrianus TrouwiD· 1 shared Leoni AbendsteiniD· 1 shared Luc S. VeenmaniD· 1 shared Thomas Harry SharpiD· 1 shared Willem E. M. NoteborniD· 1 shared

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1 shared paperSynthetic Biology

Douwe J. DijkstraORCID

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Synthetic BiologyJournal of the American Chemical SocietyPeer-reviewedMay 4, 2024

DNA nanostructure-templated antibody complexes provide insights into the geometric requirements of human complement cascade activation

Leoni Abendstein, Willem E. M. Noteborn, Luc S. Veenman…·Thomas Harry Sharp

This study uses DNA nanostructures to template IgG antibodies and investigate how IgG valency affects complement activation, revealing that antigen number correlates with complement cleavage and terminal pathway activation.

16 citations

humanproteomics

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