Leendert Adrianus Trouw

This study shows that complement proteins like C1q block FcγR engagement with IgG, reducing their role in neutrophil phagocytosis, while complement receptors still enhance bacterial clearance.

This study maps SES-related immune diversity using flow cytometry, finding lower SES associates with downregulated surface proteins and upregulated immune checkpoints.

This paper presents a cryo-ET structure of CRP bound to C1 complex and PC ligands, revealing how CRP activates complement and identifies residues for therapeutic targeting.

This study uses DNA nanostructures to template IgG antibodies and investigate how IgG valency affects complement activation, revealing that antigen number correlates with complement cleavage and terminal pathway activation.