Douwe J. Dijkstra

This study identifies a C3b-specific nanobody that binds C3b but not C3, and inhibits the alternative pathway convertases of the complement system.

This paper presents a cryo-ET structure of CRP bound to C1 complex and PC ligands, revealing how CRP activates complement and identifies residues for therapeutic targeting.

This study uses DNA nanostructures to template IgG antibodies and investigate how IgG valency affects complement activation, revealing that antigen number correlates with complement cleavage and terminal pathway activation.