Synthetic BiologyJournal of the American Chemical SocietyPeer-reviewed
DNA nanostructure-templated antibody complexes provide insights into the geometric requirements of human complement cascade activation
Leoni Abendstein, Willem E. M. Noteborn, Luc S. Veenman…·Thomas Harry Sharp
This study uses DNA nanostructures to template IgG antibodies and investigate how IgG valency affects complement activation, revealing that antigen number correlates with complement cleavage and terminal pathway activation.
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