Author

Aleksandra M. Mech

UCL Queen Square Institute of NeurologyORCID 0000-0003-0511-6048Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Giampietro SchiavoiD· 3 shared James N. SleighiD· 3 shared Adele LeggieriiD· 1 shared Anna‐Leigh BrowniD· 1 shared Caroline H. BrennaniD· 1 shared Jose Vicente Torres-PéreziD· 1 shared Sofia AnagianniiD· 1 shared Tahmina Aktar· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersNeuroscience

Giampietro SchiavoORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintJan 22, 2024

Disrupting fzd9b in zebrafish recapitulates stress- and anxiety-like behaviours associated with Williams syndrome

Jose Vicente Torres-Pérez, Adele Leggieri, Aleksandra M. Mech…·Caroline H. Brennan

The paper generates zebrafish mutants with fzd9b disruptions to study anxiety and social behaviors linked to Williams syndrome, finding altered stress responses and compensatory gene upregulation.

2 citations

zebrafishexperimental assay

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NeuroscienceFrontiers in Cellular NeurosciencePeer-reviewedAug 11, 2020

Altered sensory neuron development in CMT2D mice is site-specific and linked to increased GlyRS levels

James N. Sleigh, Aleksandra M. Mech, Tahmina Aktar…·Giampietro Schiavo

19 citations

mousestatistical model

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NeuroscienceCell Death and DiseasePeer-reviewedJul 23, 2020

Developmental demands contribute to early neuromuscular degeneration in CMT2D mice

James N. Sleigh, Aleksandra M. Mech, Giampietro Schiavo

This study examines neuromuscular junction (NMJ) pathology in CMT2D mice, finding a distal-to-proximal denervation gradient and identifying post-natal synaptic growth as a factor in neurodegeneration.

24 citations

mousestatistical model

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NeuroscienceJournal of AnatomyPeer-reviewedJun 13, 2020

Post-synaptic morphology of mouse neuromuscular junctions is linked to muscle fibre type

Aleksandra M. Mech, Anna‐Leigh Brown, Giampietro Schiavo, James N. Sleigh

This study quantifies post-synaptic NMJ morphology in different mouse muscles and finds it correlates with fibre type, not diameter, and shows NMJ growth rates vary across muscles.

43 citations

mouseimaging

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