Author

Douglas G. Fraser

Boston University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aaron B. BeeleriD· 2 shared David A. HarrisiD· 2 shared Nhat T. T. LeiD· 2 shared Robert C.C. MerceriD· 2 shared Aravind SundaravadiveluiD· 1 shared Erin Flaherty· 1 shared Giada LavignaiD· 1 shared Glenn C. TellingiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Aaron B. BeelerORCID

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2 papers

Recent·Most cited

Lysosomal Enhancement Prevents Infection with PrPSc, α-Synuclein & Tau Prions

Robert C.C. Mercer, Nhat T. T. Le, Nadia A. Mirza-Romero, Isabel C. Orbe, Erin Flaherty, Joseph P. DeFranco, Giada Lavigna, Jean R.P. Gatdula, Douglas G. Fraser, Aravind Sundaravadivelu, Janelle S. Vultaggio, Aaron B. Beeler, Roberto Chiesa, Glenn C. Telling, David A. Harris

This paper identifies elacridar as a compound that prevents prion infection by enhancing lysosomal function, showing effects against PrPSc, α-synuclein, and tau prions.

Journal of Biological Chemistry · Dec 13, 2025Peer-reviewedNeuroscience

Sigma receptor ligands are potent anti-prion compounds that act independently of sigma receptor binding

Robert C.C. Mercer, Nhat T. T. Le, Douglas G. Fraser, Mei CQ Houser, Aaron B. Beeler, David A. Harris

The paper identifies sigma receptor ligands as potent anti-prion compounds that are effective regardless of sigma receptor binding.

ACS Chemical Neuroscience · May 14, 2024Peer-reviewedNeuroscience