Marcos Parras-Moltó

This study systematically analyzes antibiotic resistance gene transfers between evolutionary distant bacteria, identifying 661 inter-phyla transfers and highlighting differences in transfer frequency and mechanisms across ARG classes and phyla.

Random forests using nucleotide-composition dissimilarity and metagenomic co-occurrence predict horizontal transfer of resistance genes between bacteria (general model AUROC 0.873); mismatch limits transfer, human and wastewater co-occurrence favors it.