Anna Johnning

This study systematically analyzes antibiotic resistance gene transfers between evolutionary distant bacteria, identifying 661 inter-phyla transfers and highlighting differences in transfer frequency and mechanisms across ARG classes and phyla.

The paper investigates how the prevalence of antibiotic resistance genes in human gut and wastewater microbiomes correlates with their dissemination among bacterial pathogens.

Random forests using nucleotide-composition dissimilarity and metagenomic co-occurrence predict horizontal transfer of resistance genes between bacteria (general model AUROC 0.873); mismatch limits transfer, human and wastewater co-occurrence favors it.