Xiao‐Kang Lun

This paper introduces ACE, a method for high-plex protein imaging in thick tissues, reducing imaging time and enabling uniform signal amplification across tissue depths.

The paper quantifies how environment, neighborhood, and cell state influence phenotypic variability in 3D spheroids using mass cytometric imaging and a linear model.

This paper introduces DISCO, a method to infer single-cell signaling dynamics from snapshot data, revealing cell-to-cell variation in MAPK/ERK signaling and its dependence on initial states.

The paper analyzes the human kinome and phosphatome to identify signaling networks altered by protein overexpression, revealing novel relationships and mechanisms of cancer progression.