Author

Kuanwei Sheng

Harvard UniversityORCID 0000-0002-7155-9915Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Hanquan SuiD· 2 shared Arya Parlapalli· 1 shared Bin DuaniD· 1 shared Charlotte GeorgeiD· 1 shared Chenghang Chuck ZongiD· 1 shared Dawen CaiiD· 1 shared German Albert PihaniD· 1 shared Gokul GowriiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

Hanquan SuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

High-plex protein imaging across thick tissue by synchronized amplification

Kuanwei Sheng, Hanquan Su, Gokul Gowri, Maxwell Furman, Matthew P. Serrata, Lili Du, Charlotte George, Michel Nofal, Ryan McMillan, Kaibo Ma, Xiao‐Kang Lun, 佐々木浩, Jiyoun Jeong, German Albert Pihan, Peng Yin

This paper introduces ACE, a method for high-plex protein imaging in thick tissues, reducing imaging time and enabling uniform signal amplification across tissue depths.

bioRxiv · Oct 14, 2026 · PreprintBioengineering

A parallelly distributed microscope and software system for scalable high-throughput multispectral 3D imaging

Hehai Jiang, Logan A. Walker, Ye Li, Bin Duan, Xiaoman Niu, Jung‐Chien Hsieh, Peng Yin, Mou-Chi Cheng, Hanquan Su, Kuanwei Sheng, Jessica P. Tang, Kenneth Athukorala, Stacey Greene, Ruby Pan, Arya Parlapalli, , Dawen Cai

The paper introduces a parallelly distributed microscope and software system for high-throughput multispectral 3D imaging with high resolution and data throughput.

bioRxiv · May 31, 2025 · PreprintBioengineering

Topologically Dependent Abundance of Spontaneous DNA Damage in Single Human Cells

Qiangyuan Zhu, Yichi Niu, Michael C. Gundry, Kuanwei Sheng, Muchun Niu, Chenghang Chuck Zong

This paper introduces a new single-cell WGA method to detect DNA damage-associated variants and finds that dSNV abundance is linked to genome topological compartments.

bioRxiv · Dec 23, 2019 · PreprintGenomics