Author

Hongjiu Zhang

Microsoft (United States)ORCID 0000-0003-0545-5613Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 3 Approach:benchmark study· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Yuanfang GuaniD· 4 shared Adriana SalcedoiD· 2 shared Alex Buchanan· 2 shared Amit G. DeshwariD· 2 shared David C. WedgeiD· 2 shared Dimitris AnastassiouiD· 2 shared Imaad Umar· 2 shared Jeff A. WintersingeriD· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBioinformatics

Yuanfang GuanORCID

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4 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJun 14, 2022

Crowd-sourced benchmarking of single-sample tumour subclonal reconstruction

Adriana Salcedo, Maxime Tarabichi, Alex Buchanan…·Paul Christopher Boutros

The paper benchmarks 31 subclonal reconstruction algorithms on simulated tumours, finding that algorithm choice significantly impacts performance and no single algorithm excels across all tasks.

1 citation

whole-exome sequencingbenchmark study

𝕏 PostBluesky

NeuroscienceJournal of NeurosciencePeer-reviewedJan 18, 2022

Impaired oligodendrocyte maturation is an early feature in SCA3 disease pathogenesis

Kristen H. Schuster, Annie J. Zalon, Hongjiu Zhang…·Hayley S. McLoughlin

This study identifies impaired oligodendrocyte maturation as an early feature in SCA3 disease pathogenesis through longitudinal transcriptomic analysis and functional validation in mice.

55 citationstop 3%

mousebulk RNA-seq

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BioinformaticsNature BiotechnologyPeer-reviewedJan 1, 2020

Creating Standards for Evaluating Tumour Subclonal Reconstruction

DREAM SMC-Het Participants, Adriana Salcedo, Maxime Tarabichi…·Paul Christopher Boutros

This study develops quantitative metrics and simulated datasets to evaluate subclonal reconstruction methods in tumours.

91 citationstop 2%

whole-genome sequencingsimulation

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Systems BiologybioRxivPreprintAug 13, 2019

Chromosome 17: neXt-MP50 C-HPP Challenge Completed

Hongjiu Zhang, Omer Siddiqui, Yuanfang Guan, Gilbert S. Omenn

The paper reports a 50% reduction in PE2,3,4 missing proteins on Chromosome 17 using protein-level evidence from proteomics data.

DOI 10.1101/734657

humanproteomics

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