Naoaki Sakamoto

This study examines the transcriptomic effects of HDAC inhibitors on feline cells, finding organ-specific responses and differential gene expression patterns compared to human cells.

The paper uses whole-genome sequencing of CRFK and PG-4 cells to infer the phenotype of their donor cats, identifying coat and iris color traits.

The paper analyzes c-KIT isoform expression across five mammals, finding conserved tissue-specific patterns and identifying regulatory factors for alternative splicing.

The paper updates the draft genome of Hemicentrotus pulcherrimus using long-read sequencing, achieving higher continuity and resolution compared to the previous assembly.

This study investigates the role of HpCTCF in sea urchin early development, showing it is essential for mitotic progression but not for later larval development.

MaChIAto profiles genomic and epigenomic features affecting CRISPR edit efficiency and accuracy, revealing context-dependent factors influencing knock-out, knock-in, and Prime Editing outcomes.

The paper shows that omeprazole disrupts F-actin polarity in sea urchin embryos, leading to partial exogastrulation by affecting secondary invagination.

The paper shows that long nucleosome-excluding DNA sequences can act as chromatin insulators without requiring bound loop-forming proteins, using simulations and human genome analysis.