Tetsushi Sakuma

This study shows Hox2 is required for atrial siphon fusion in Ciona, with Hox2-knockout animals retaining two siphons and lacking cupular organs.

This paper develops a mutation-agnostic gene insertion therapy for RHO-adRP using ZF-ND1-mediated HITI and validates its efficacy and safety in preclinical models.

This study investigates the functional impact of pathogenic RHD mutations in Runx2 on skeletal and dental development in a mouse model of cleidocranial dysplasia.

The paper compares trans-chromosomic rodent models and finds rats show improved somatic hypermutation and class-switch recombination compared to mice.

This study investigates how sclerostin modulates mineralization and stiffness in fibrocartilaginous entheses to maintain mechanical integrity.

MaChIAto profiles genomic and epigenomic features affecting CRISPR edit efficiency and accuracy, revealing context-dependent factors influencing knock-out, knock-in, and Prime Editing outcomes.

This paper describes the creation of the first non-human primate model of familial Alzheimer's disease using genome editing to introduce a PSEN1 mutation associated with early-onset AD.

The paper identifies a MMD2 mutation causing aggressive periodontitis and neutropenia in a Japanese family, showing impaired granulocyte differentiation and immune function.