Takashi Yamamoto

Possible function of Hox2 in atrial siphon fusion of the ascidian Ciona

This study shows Hox2 is required for atrial siphon fusion in Ciona, with Hox2-knockout animals retaining two siphons and lacking cupular organs.

Mutation-agnostic gene insertion therapy for RHO-associated autosomal dominant retinitis pigmentosa using zinc finger nucleases

This paper develops a mutation-agnostic gene insertion therapy for RHO-adRP using ZF-ND1-mediated HITI and validates its efficacy and safety in preclinical models.

Functional impact of pathogenic Runt domain mutations in Runx2 on skeletal and dental development in cleidocranial dysplasia

This study investigates the functional impact of pathogenic RHD mutations in Runx2 on skeletal and dental development in a mouse model of cleidocranial dysplasia.

Comparative analysis of trans-chromosomic rodent models reveals improved somatic hypermutation and class-switch recombination in rats

The paper compares trans-chromosomic rodent models and finds rats show improved somatic hypermutation and class-switch recombination compared to mice.

Sclerostin modulates the degree of mineralization and the stiffness profile of the fibrocartilaginous enthesis for mechanical tissue integrity

This study investigates how sclerostin modulates mineralization and stiffness in fibrocartilaginous entheses to maintain mechanical integrity.

Transcription-coupled changes in higher-order genomic structure and transcription hub viscosity prolong enhancer-promoter connectivity

The paper examines enhancer-promoter interactions in mouse embryonic stem cells, finding that transcriptional activity increases genomic viscosity, stabilizing these interactions.

Assembly of continuous high-resolution draft genome sequence of Hemicentrotus pulcherrimus using long-read sequencing

The paper updates the draft genome of Hemicentrotus pulcherrimus using long-read sequencing, achieving higher continuity and resolution compared to the previous assembly.

The Crucial Role of CTCF in Mitotic Progression during Early Development of Sea Urchin.

This study investigates the role of HpCTCF in sea urchin early development, showing it is essential for mitotic progression but not for later larval development.

STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity

The paper develops a STREAMING-tag system to study spatiotemporal relationships between transcriptional factors and activity in living cells.

Detailed profiling with MaChIAto reveals various genomic and epigenomic features affecting the efficacy of knock-out, short homology-based knock-in and Prime Editing

MaChIAto profiles genomic and epigenomic features affecting CRISPR edit efficiency and accuracy, revealing context-dependent factors influencing knock-out, knock-in, and Prime Editing outcomes.

Partial exogastrulation due to apical-basal polarity of F-actin distribution disruption in sea urchin embryo by omeprazole

The paper shows that omeprazole disrupts F-actin polarity in sea urchin embryos, leading to partial exogastrulation by affecting secondary invagination.

A non-human primate model of familial Alzheimer's disease

This paper describes the creation of the first non-human primate model of familial Alzheimer's disease using genome editing to introduce a PSEN1 mutation associated with early-onset AD.

Genome-wide analysis of transcriptional bursting-induced noise in mammalian cells

This study investigates transcriptional bursting kinetics in mESCs using scRNA-seq and identifies regulatory factors and pathways influencing gene expression noise.