Akinori Awazu

Transcriptomic response to histone deacetylase inhibitors in cultured feline cells

This study examines the transcriptomic effects of HDAC inhibitors on feline cells, finding organ-specific responses and differential gene expression patterns compared to human cells.

Whole-genome sequencing of CRFK and PG-4 cells to infer the phenotype of the original donor cats

The paper uses whole-genome sequencing of CRFK and PG-4 cells to infer the phenotype of their donor cats, identifying coat and iris color traits.

Common tissue-specific expressions and regulatory mechanisms of c-KIT isoforms with and without GNNK and GNSK sequences across five mammals

The paper analyzes c-KIT isoform expression across five mammals, finding conserved tissue-specific patterns and identifying regulatory factors for alternative splicing.

Potential multiple disease progression pathways in female patients with Alzheimer's disease inferred from transcriptome and epigenome data of the dorsolateral prefrontal cortex

Identification of anisotropy in chromosome dynamics by principal component analysis using integrated spatial genomics

The paper uses principal component analysis on spatial genomics data to identify isotropic and anisotropic modes of chromosome fluctuations in mouse embryonic stem cells.

Assembly of continuous high-resolution draft genome sequence of Hemicentrotus pulcherrimus using long-read sequencing

The paper updates the draft genome of Hemicentrotus pulcherrimus using long-read sequencing, achieving higher continuity and resolution compared to the previous assembly.

The Crucial Role of CTCF in Mitotic Progression during Early Development of Sea Urchin.

This study investigates the role of HpCTCF in sea urchin early development, showing it is essential for mitotic progression but not for later larval development.

Detailed profiling with MaChIAto reveals various genomic and epigenomic features affecting the efficacy of knock-out, short homology-based knock-in and Prime Editing

MaChIAto profiles genomic and epigenomic features affecting CRISPR edit efficiency and accuracy, revealing context-dependent factors influencing knock-out, knock-in, and Prime Editing outcomes.

Partial exogastrulation due to apical-basal polarity of F-actin distribution disruption in sea urchin embryo by omeprazole

The paper shows that omeprazole disrupts F-actin polarity in sea urchin embryos, leading to partial exogastrulation by affecting secondary invagination.

Identification of transcription termination defects at DNA hypomethylated transcription termination sites in DNA methyltransferase 3a-deficient vertebrates.

The paper identifies transcription termination defects at hypomethylated TTSs in Dnmt3a-deficient vertebrates using methylome and transcriptome data.

Insulator Activities of Nucleosome-Excluding DNA Sequences Without Bound Chromatin Looping Proteins

The paper shows that long nucleosome-excluding DNA sequences can act as chromatin insulators without requiring bound loop-forming proteins, using simulations and human genome analysis.

Gauss-power mixing distributions comprehensively describe stochastic variations in RNA-seq data

The paper analyzes RNA-seq data from Arabidopsis thaliana and Saccharomyces cerevisiae to show that gene expression distributions can be described by Gauss-power mixing distributions, with functional implications for gene types.