Author

Matthew J. Wirick

Central Michigan UniversityORCID 0000-0003-0557-3783Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Amelia F. Alessi· 3 shared Himani GalagaliiD· 3 shared Xantha KarpiD· 3 shared Benjamin S. OlsoniD· 2 shared Isaac T. SmithiD· 2 shared John K. KimiD· 2 shared Kevin J. RankeiD· 2 shared Kyal LalkiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Amelia F. Alessi

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJul 20, 2026

FOXO/DAF-16 modulates the transcription factor ROR/NHR-23 and inhibits the let-7 microRNA to maintain multipotency during dauer

Himani Galagali, Matthew J. Wirick, Amelia F. Alessi…·John K. Kim

This study identifies DAF-16/FOXO's role in repressing let-7 microRNA and NHR-23 to maintain multipotency during dauer in C. elegans.

DOI 10.64898/2026.07.18.739353

C. elegansstatistical model

𝕏 PostBluesky

Developmental BiologybioRxivPreprintJun 18, 2025

daf-16/FOXO activity before dauer diapause anticipates dauer exit and post-dauer development via DAF-12/NHR

Matthew J. Wirick, Isaac T. Smith, Benjamin S. Olson…·Xantha Karp

This study shows that daf-16/FOXO activity before dauer diapause enables dauer exit and post-dauer development by promoting cholesterol retention and DAF-12 ligand synthesis.

DOI 10.1101/2025.06.18.660181

C. elegansexperimental assay

𝕏 PostBluesky

GeneticsPLoS GeneticsPeer-reviewedNov 15, 2021

daf-16/FOXO blocks adult cell fate in Caenorhabditis elegans dauer larvae via lin-41/TRIM71

Matthew J. Wirick, Allison R. Cale, Isaac T. Smith…·Xantha Karp

This study shows that daf-16/FOXO promotes multipotency in C. elegans dauer larvae by upregulating lin-41/TRIM71, which blocks premature adult cell fate markers.

12 citations

C. elegansstatistical model

𝕏 PostBluesky