Valentina Lo Sardo

The paper identifies cell type-specific and sex-specific transcriptional dysregulation in islets of Langerhans in Down syndrome mice, linking it to increased T2D risk.

This study shows that allelic variation at the 9p21.3 locus affects RNA splicing in vascular smooth muscle cells, leading to phenotypic changes linked to coronary artery disease.

The paper identifies a common fibro-adipogenic progenitor population in both white and brown adipose tissue using single-cell RNA sequencing and validates its physiological relevance through comparison with in vivo data.

This study shows that the 9p21.3 CAD risk locus drives vascular smooth muscle cells to an osteochondrogenic state through ANRIL expression, leading to arterial calcification.