Cyrus R. Sethna

Genome-wide cell type-specific and sex-specific transcriptional dysregulation in the islet of Langerhans underlies islet dysfunction in Down syndrome-related diabetes

The paper identifies cell type-specific and sex-specific transcriptional dysregulation in islets of Langerhans in Down syndrome mice, linking it to increased T2D risk.

Generation of photocaged nanobodies for in vivo applications using genetic code expansion and computationally guided protein engineering

This paper develops photocaged nanobodies for in vivo applications using genetic code expansion and computational methods to control protein interactions with light.