Bayley J. Waters

Genome-wide cell type-specific and sex-specific transcriptional dysregulation in the islet of Langerhans underlies islet dysfunction in Down syndrome-related diabetes

The paper identifies cell type-specific and sex-specific transcriptional dysregulation in islets of Langerhans in Down syndrome mice, linking it to increased T2D risk.

Islet architecture in adult mice is actively maintained by Robo2 expression in beta cells

This study shows that Robo2 in adult beta cells actively maintains islet architecture, as its deletion leads to loss of architecture without affecting beta cell identity or function.