Author

José Verdezoto Mosquera

University of VirginiaORCID 0000-0002-2816-2250Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 5 Approach:statistical model· 5 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Clint L. MilleriD· 5 shared Adam W. TurneriD· 4 shared Doris WongiD· 4 shared Yipei SongiD· 4 shared Chani J. HodonskyiD· 3 shared Gaelle E AugusteiD· 3 shared Jason Ciril KovaciciD· 3 shared Johan BjörkegreniD· 3 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersGenomics

Clint L. MillerORCID

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5 papers

Recent·Most cited

The 9p21.3 coronary artery disease risk locus drives vascular smooth muscle cells to an osteochondrogenic state

Elsa Salido, Carolina de Medeiros Vieira, José Verdezoto Mosquera, Rohan Zade, Parth Parikh, Shraddha Suryavanshi, Clint L. Miller, Valentina Lo Sardo

This study shows that the 9p21.3 CAD risk locus drives vascular smooth muscle cells to an osteochondrogenic state through ANRIL expression, leading to arterial calcification.

Arteriosclerosis Thrombosis and Vascular Biology · Mar 27, 2025Peer-reviewedCell Biology

Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis

José Verdezoto Mosquera, Gaelle E Auguste, Doris Wong, Adam W. Turner, Chani J. Hodonsky, Astrid Catalina Álvarez-Yela, Yipei Song, Qi Cheng, Christian Lacks Lino Cardenas, Konstantinos Theofilatos, Maxime M. Bos, Maryam Kavousi, Patricia A. Peyser, Manuel Mayr, Jason Ciril Kovacic, , Clint L. Miller

This study performs a meta-analysis of scRNA-seq datasets to map human atherosclerosis cell diversity and identifies disease-relevant vascular cell states and markers.

Cell Reports · Nov 1, 2023Peer-reviewedGenomics

FHL5 controls vascular disease-associated gene programs in smooth muscle cells

Doris Wong, Gaelle E Auguste, Christian Lacks Lino Cardenas, Adam W. Turner, Yixuan Chen, Yipei Song, Lijiang Ma, R. Noah Perry, Rédouane Aherrahrou, Maniselvan Kuppusamy, Chaojie Yang, José Verdezoto Mosquera, Collin Dube, Mohammad Daud Khan, Meredith Palmore, , Clint L. Miller

This study identifies FHL5 as a causal gene for vascular disease risk through eQTL colocalization and functional analyses, showing its role in vascular remodeling and calcification.

Circulation Research · Apr 5, 2023Peer-reviewedGenomics

Cell-specific chromatin landscape of human coronary artery resolves regulatory mechanisms of disease risk

Adam W. Turner, Shengen Shawn Hu, José Verdezoto Mosquera, Wei Feng, Chani J. Hodonsky, Doris Wong, Gaelle E Auguste, Yipei Song, Katia Sol‐Church, Emily Farber, Soumya Kundu, Anshul Bharat Kundaje, Nicolas Gabriel Lopez, Lijiang Ma, Saikat Ghosh, , Clint L. Miller

The paper uses single-cell ATAC-seq to analyze coronary artery cells from CAD patients, identifying regulatory mechanisms and risk variants associated with disease.

Nature Genetics · May 19, 2022Peer-reviewedGenomics

Single-cell RNA-seq analysis of human coronary arteries using an enhanced workflow reveals SMC transitions and candidate drug targets

Wei Feng, Chani J. Hodonsky, Adam W. Turner, Doris Wong, Yipei Song, Nelson B. Barrientos, José Verdezoto Mosquera, Clint L. Miller

The paper applies an enhanced scRNA-seq workflow to human coronary artery data, revealing SMC transitions and drug targets through ligand-receptor analysis and an interactive web tool.

bioRxiv · Oct 27, 2020 · PreprintGenomics