NeuroscienceOpen BiologyPeer-reviewed
Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates that reduce surface AMPA receptor expression in primary neurons
Jocelyn Widagdo, Saumya R. Udagedara, Nishita Bhembre…·Mihwa Lee
This study shows that ALS-linked SFPQ mutations increase zinc binding and cytoplasmic aggregation, reducing surface AMPA receptor subunit GluA1 in neurons.
20 citations