Jiji Chen

This paper introduces iSiMM, a method for tracking single molecules in live tissues, and demonstrates its application to study protein dynamics in mice.

This study identifies a lipid cue that drives the subcellular localization of a bacterial transmembrane protein, ShfA, by binding to undecaprenyl phosphate.

The paper shows that the CENP-A chaperone complex forms shell-like structures around centromeres in interphase, essential for centromere architecture and genome stability.

This paper introduces an algorithm to reconstruct 3D molecular orientation and density from polarized fluorescence microscopy data, demonstrating its application on biological structures and dynamics.

This study introduces a new COSI technology platform that integrates single-cell transcriptomics with super-resolution imaging to analyze liver sinusoidal endothelial cell fenestrations and their association with metabolic diseases.

The paper introduces a polarized dual-view light-sheet microscope to recover 3D orientations and positions of fluorescent dipoles, validated with experiments on biological samples.

This study shows that bacterial differentiation through altruistic feeding and cell-cell signaling increases phenotypic heterogeneity, enhancing population resilience to environmental changes.

This study identifies U2AF's role in regulating mitochondrial function by controlling translation and localization of nuclear-encoded mitochondrial mRNAs, with implications for disease.